Prognostic scores in PTCL
When you are diagnosed with peripheral T-cell lymphoma (PTCL), your doctors may use prognostic
scores, which are tools that estimate how the lymphoma might behave and help guide treatment
planning.These tools take into account a variety of clinical factors to help predict overall outlook (or
prognosis).
It is important to understand that most of these scores were developed when standard chemotherapy
was the main treatment option. Today, with newer targeted and immune-based therapies available,
these older tools may not fully reflect outcomes in the modern treatment era. Still, they remain useful
for giving a general sense of risk, helping doctors tailor treatments, and supporting open conversations
about what you can expect moving forward.
Below are some prognostic scores used in PTCL.
When you are diagnosed with peripheral T-cell lymphoma (PTCL), your doctors may use prognostic scores, which are tools that estimate how the lymphoma might behave and help guide treatment planning.These tools take into account a variety of clinical factors to help predict overall outlook (or prognosis).
It is important to understand that most of these scores were developed when standard chemotherapy was the main treatment option. Today, with newer targeted and immune-based therapies available, these older tools may not fully reflect outcomes in the modern treatment era.
Still, they remain useful for giving a general sense of risk, helping doctors tailor treatments, and supporting open conversations about what you can expect moving forward.
Below are some prognostic scores used in PTCL.
When you are diagnosed with peripheral T-cell lymphoma (PTCL), your doctors may use prognostic
scores, which are tools that estimate how the lymphoma might behave and help guide treatment
planning.These tools take into account a variety of clinical factors to help predict overall outlook (or
prognosis).
It is important to understand that most of these scores were developed when standard chemotherapy was the main treatment option. Today, with newer targeted and immune-based
therapies available, these older tools may not fully reflect outcomes in the modern treatment era.
Still, they remain useful for giving a general sense of risk, helping doctors tailor treatments, and supporting open conversations about what you can expect moving forward.
Below are some prognostic scores used in PTCL.
International Prognostic Index (IPI)
The International Prognostic Index, or IPI, is one of the most widely used scoring systems to help
doctors understand the likely course of many types of non-Hodgkin lymphomas. Originally designed
for aggressive B-cell lymphomas, the IPI has been validated and is also used for T-cell lymphomas.
The IPI looks at a few key factors:
Age
Overall health and daily activity level
Stage of the lymphoma (how far it has spread)
Whether the lymphoma has affected more than one organ outside the lymph nodes
Certain blood test results
The International Prognostic Index, or IPI, is one of the most widely used scoring systems to help
doctors understand the likely course of many types of non-Hodgkin lymphomas. Originally designed for aggressive B-cell lymphomas, the IPI has been validated and is also used for T-cell lymphomas. The IPI looks at a few key factors:
Age
Overall health and daily activity level
Stage of the lymphoma (how far it has spread)
Whether the lymphoma has affected more than one organ outside the lymph nodes
Certain blood test results
The International Prognostic Index, or IPI, is one of the most widely used scoring systems to help
doctors understand the likely course of many types of non-Hodgkin lymphomas. Originally designed for aggressive B-cell lymphomas, the IPI has been validated and is also used for T-cell lymphomas. The IPI looks at a few key factors:
Age
Overall health and daily activity level
Stage of the lymphoma (how far it has spread)
Whether the lymphoma has affected more than one organ outside the lymph nodes
Certain blood test results
Calculate the IPI here
The higher the number of risk factors, the higher the “risk group.” Risk groups range
from low to high, with “risk” meaning the likelihood that the lymphoma might behave
more aggressively.
Prognostic Index for T-cell Lymphoma (PIT)
The Prognostic Index for T-cell lymphoma (PIT) is a scoring system created specifically for patients
with PTCL. The PIT score considers four key factors:
Age
How well a person is able to carry out daily activities (performance status)
Certain blood test results
Whether the lymphoma has spread outside the lymph nodes
Like the IPI, the higher the number of risk factors, the higher the “risk group.” Risk groups range from
low to high, with “risk” meaning the likelihood that the lymphoma might behave more aggressively.
The Prognostic Index for T-cell lymphoma (PIT) is a scoring system created specifically for patients
with PTCL. The PIT score considers four key factors:
Age
How well a person is able to carry out daily activities (performance status)
Certain blood test results
Whether the lymphoma has spread outside the lymph nodes
Like the IPI, the higher the number of risk factors, the higher the “risk group.” Risk groups range
from low to high, with “risk” meaning the likelihood that the lymphoma might behave more aggressively.
Prognostic Index for Relapsed/Refractory Mature T-Cell and NK-Cell
Lymphomas (PIRT):
Prognostic Index for Relapsed/Refractory Mature T-Cell and NK-Cell Lymphomas (PIRT):
The Prognostic Index for PTCL (PIRT) is a newer scoring system designed specifically for patients with
PTCL whose disease has come back. Its components include:
Age
Overall activity level (performance status)
Blood test results
Features of the lymphoma itself (such as how far it has spread and certain disease characteristics)
By combining these factors, the PIRT places patients into different risk groups. These groups help
doctors estimate outlook, guide treatment discussions, and better reflect the outcomes seen in more modern treatment approaches compared with older scoring systems.
The Prognostic Index for PTCL (PIRT) is a newer scoring system designed specifically for patients with PTCL whose disease has come back. Its components include:
Age
Overall activity level (performance status)
Blood test results
Features of the lymphoma itself (such as how far it has spread and certain disease
characteristics)
By combining these factors, the PIRT places patients into different risk groups. These groups help
doctors estimate outlook, guide treatment discussions, and better reflect the outcomes seen in more modern treatment approaches compared with older scoring systems.
Calculate your PIRT score here
Estimate your personalized PIRT risk group based on age, performance status,
blood results, and disease features.
Estimate your personalized PIRT risk group based on age, performance status, blood results, and disease features.
What Do These Scores Mean for You?
Prognostic scores can sound intimidating, but it’s important to know what they really mean.
Guides, not answers: These scores give your healthcare team a general sense of how the disease
may behave and help with treatment planning. They cannot predict exactly how any one person will do.Not a diagnosis: A score is not the whole story. Many patients with high scores still do well,
especially with the newer treatments available today. If you see a prognostic score in your medical
report, try not to worry—it is just one of many tools your doctors use to provide the best care. If you
have questions, your care team is always there to explain and support you.Personalized care: These tools are never used in isolation. Your doctor will always look at the bigger
picture—your overall health, your personal preferences, your test results, and the latest treatment options—to create the most appropriate care plan for you.
Remember: Prognostic scores can give some general guidance, but they don’t determine your future.
What truly matters is you, and your doctors will always personalize your care to give you the best chance for a positive outcome.
Prognostic scores can sound intimidating, but it’s important to know what they really mean.
Guides, not answers: These scores give your healthcare team a general sense of how the disease
may behave and help with treatment planning. They cannot predict exactly how any one person will do.Not a diagnosis: A score is not the whole story. Many patients with high scores still do well, especially with
the newer treatments available today. If you see a prognostic score in your medical report, try not to
worry—it is just one of many tools your doctors use to
provide the best care. If you have questions, your care team is always there to explain and support you.Personalized care: These tools are never used in isolation. Your doctor will always look at the bigger
picture—your overall health, your personal preferences, your test results, and the latest treatment options—to create the most appropriate care plan for you.
Remember: Prognostic scores can give some general guidance, but they don’t determine your future.
What truly matters is you, and your doctors will always personalize your care to give you the best chance for a positive outcome.
Prognostic scores can sound intimidating, but it’s important to know what they really mean.
Guides, not answers: These scores give your healthcare team a general sense of how the
disease may behave and help with treatment planning. They cannot predict exactly how any one person will do.Not a diagnosis: A score is not the whole story. Many patients with high scores still do well,
especially with the newer treatments available today. If you see a prognostic score in your medical report, try not to worry—it is just one of many tools your doctors use to provide the best care. If you have questions, your care team is always there to explain and support you.Personalized care: These tools are never used in isolation. Your doctor will always look at the bigger picture—your overall health, your personal preferences, your test results, and the latest treatment options—to create the most appropriate care plan for you.
Remember: Prognostic scores can give some general guidance, but they don’t determine your future.
What truly matters is you, and your doctors will always personalize your care to give you the best chance for a positive outcome.