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What is PTCL?

Signs and Symptoms of Peripheral
T-cell Lymphoma

Signs and Symptoms of Peripheral
T-cell Lymphoma

Signs and Symptoms of Peripheral
T-cell Lymphoma

Peripheral T-cell lymphoma (PTCL) can affect people in different ways. Some individuals may feel very
unwell, while others may have no noticeable symptoms. However, there are certain signs and
symptoms to be aware of:

Peripheral T-cell lymphoma (PTCL) can affect people in different ways. Some individuals may feel very unwell, while others may have no noticeable symptoms. However, there are certain signs and symptoms to be aware of:

Peripheral T-cell lymphoma (PTCL) can affect people in different ways. Some individuals may feel very unwell, while others may have no noticeable symptoms. However, there are certain signs and
symptoms to be aware of:

Common Symptoms:

✔ Swollen lymph nodes (often painless)
✔ Unexplained weight loss
✔ Fever and night sweats
✔ Persistent loss of energy (Fatigue)
✔ Mouth sores

Other Possible Symptoms:

✔ Skin changes such as rashes, red or dark patches
✔ Itching without a known cause
✔ Symptoms related to organ involvement with cancer. Few examples: 
○ Abdomen: Swelling or discomfort due to an enlarged spleen or liver
○ Nose: Nosebleeds and Nasal congestion
○ Hair loss & Nail changes

✔ Skin changes such as rashes, red or dark patches
✔ Itching without a known cause
✔ Symptoms related to organ involvement with cancer.
Few examples: 
○ Abdomen: Swelling or discomfort due to an enlarged spleen or liver
○ Nose: Nosebleeds and Nasal congestion
○ Hair loss & Nail changes

It’s important to note that these symptoms are nonspecific, meaning they can be caused by many
different conditions and do not necessarily mean one has lymphoma or cancer. Because these
symptoms can overlap with many other medical conditions, a biopsy and specialized tests are typically
required to make an accurate diagnosis.

It’s important to note that these symptoms are nonspecific, meaning they can be caused by many different conditions and do not necessarily mean one has lymphoma or cancer. Because these symptoms can
overlap with many other medical conditions, a biopsy and
specialized tests are typically required to make an
accurate diagnosis.

It’s important to note that these symptoms are nonspecific, meaning they can be caused by many
different conditions and do not necessarily mean one has lymphoma or cancer. Because these
symptoms can overlap with many other medical conditions, a biopsy and specialized tests are typically required to make an accurate diagnosis.

A human body with different signs/ symptoms

A human body with different signs/ symptoms

The image shows common
symptoms people with Peripheral
T-Cell Lymphoma (PTCL) may experience.

PTCL can affect many parts of
the body: lymph nodes, skin, gut,
blood, and organs. Symptoms vary widely.

The image shows common symptoms people with Peripheral T-Cell Lymphoma (PTCL) may experience. PTCL can affect many parts of the body: lymph nodes,
skin, gut, blood, and organs. Symptoms vary widely.

A human body with different signs/ symptoms

The image shows common symptoms people with Peripheral T-Cell Lymphoma
(PTCL) may experience. PTCL can affect many parts of the body: lymph nodes,
skin, gut, blood, and organs. Symptoms vary widely.

Clinical Indicators of PTCL Recurrence

Clinical Indicators of PTCL Recurrence

Clinical Indicators of PTCL Recurrence

Key systemic and localized signs may signal relapsed/refractory disease, including unexplained fevers, weight loss, new lymphadenopathy, or organ-related discomfort.

Key systemic and localized signs may signal
relapsed/refractory disease, including unexplained fevers,
weight loss, new lymphadenopathy, or organ-related
discomfort.

Key systemic and localized signs may signal relapsed/refractory disease, including unexplained fevers, weight loss, new lymphadenopathy, or organ-related discomfort.

Related Reference

Related Reference

Clinical Guidelines for Diagnosis, Treatment, and Follow-Up of Peripheral T- and NK-Cell Lymphomas (ESMO–EHA 2025)

d’Amore F, Federico M, de Leval L, et al. Peripheral T‐ and natural killer‐cell lymphomas: ESMO‐EHA Clinical Practice Guideline for diagnosis, treatment, and follow‐up. Hemasphere. 2025 May 7;9(5):e70128.

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Evaluating Front-Line Anthracycline-Based Chemotherapy Regimens in PTCL: A Systematic Review & Meta-Analysis

AbouYabis AN, Shenoy PJ, Sinha R, Flowers CR, Lechowicz MJ. A Systematic Review and Meta-Analysis of Front-line Anthracycline-Based Chemotherapy Regimens for Peripheral T-Cell Lymphoma. ISRN Hematol. 2011 Jun 16;2011:623924.

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